PTH-METHIONINE

  • Name: PTH-METHIONINE
  • CAS: 4370-90-5
  • Purity: 99%
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Details

Chinese factory supply PTH-METHIONINE 4370-90-5 in stock with high standard

  • Molecular Formula: C12H14 N2 O S2
  • Molecular Weight: 266.388
  • Vapor Pressure: 4.15E-06mmHg at 25°C 
  • Melting Point: 180°C 
  • Boiling Point: 384.2°Cat760mmHg 
  • PKA: 10.85±0.40(Predicted) 
  • Flash Point: 186.2°C 
  • PSA： 89.73000 
  • Density: 1.32g/cm3 
  • LogP: 2.42320 

PTH-METHIONINE(Cas 4370-90-5) Usage

General Description

PTH-methionine is a synthetic version of parathyroid hormone (PTH) that contains a modified form of the amino acid methionine. PTH-methionine acts as an agonist for the PTH receptor, promoting the release of calcium from bone, reabsorption of calcium in the kidneys, and activation of vitamin D in the kidneys, which ultimately increases serum calcium levels. This synthetic hormone is used in the treatment of hypoparathyroidism, a condition characterized by low levels of PTH, as it can effectively regulate calcium and phosphate metabolism in the body. PTH-methionine is administered through injection and is a valuable therapeutic option for managing conditions related to calcium regulation.

InChI:InChI=1/C12H14N2OS2/c1-17-8-7-10-11(15)14(12(16)13-10)9-5-3-2-4-6-9/h2-6,10H,7-8H2,1H3,(H,13,16)

4370-90-5 Relevant articles

Enantioselective Synthesis of 5,5-Disubstituted Hydantoins by Br?nsted Base/H-Bond Catalyst Assisted Michael Reactions of a Design Template

Izquierdo, Joseba,Etxabe, Julen,Du?abeitia, Eider,Landa, Aitor,Oiarbide, Mikel,Palomo, Claudio

supporting information, p. 7217 - 7227 (2018/05/04)

A new method for the enantioselective sy...

4370-90-5 Process route

phenyl isothiocyanate
103-72-0

phenyl isothiocyanate

DL-methionine
59-51-8,26062-47-5,58576-49-1

DL-methionine

5-[2-(methylthio)ethyl]-3-phenyl-2-thioxoimidazolidin-4-one
4370-90-5

5-[2-(methylthio)ethyl]-3-phenyl-2-thioxoimidazolidin-4-one

Conditions
Conditions Yield
phenyl isothiocyanate; DL-methionine; With triethylamine; In 1,4-dioxane; water; at 0 ℃;
With hydrogenchloride; In 1,4-dioxane; water; at 0 - 50 ℃; for 12h; pH=Ca. 2;
70%
With pyridine; sodium hydroxide; und Erhitzen des Reaktionsprodukts mit wss.HCl;
5-[2-(methylthio)ethyl]-3-phenyl-2-thioxoimidazolidin-4-one
4370-90-5

5-[2-(methylthio)ethyl]-3-phenyl-2-thioxoimidazolidin-4-one

Conditions
Conditions Yield
/BRN= 471392/, 1) L-Methionin, wss. Dioxan, Na2CO3, N2, 40grad, Kond., 2) konz. HCl, N2, 40grad;
(yield)92percent;

4370-90-5 Upstream products

  • 103-72-0
    103-72-0

    phenyl isothiocyanate

  • 59-51-8
    59-51-8

    DL-methionine

4370-90-5 Downstream products

  • 1062634-87-0
    1062634-87-0

    [CuCl(5-[2-(methylthio)ethyl]-3-phenyl-2-thioxoimidazolidin-4-one(-1H))]2

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