![1-[(4-chlorophenyl)benzyl]piperazinium chloride](/upload/2026/6/bbd5377db1ca48a19d4d5f464d4bbaec_69497792-2862-4af1-be0c-16c62882dc18.png)
Details
Manufacturer supply 1,2,4,5-Tetrafluorobenzene 327-54-8 with sufficient stock and high standard
- Molecular Formula: C6H2F4
- Molecular Weight: 150.075
- Appearance/Colour: Clear colourless liquid
- Vapor Pressure: 64.2mmHg at 25°C
- Melting Point: 4 °C(lit.)
- Refractive Index: n20/D 1.407(lit.)
- Boiling Point: 90.2 °C at 760 mmHg
- Flash Point: 16.1 °C
- PSA： 0.00000
- Density: 1.412 g/cm3
- LogP: 2.24300
1,2,4,5-Tetrafluorobenzene(Cas 327-54-8) Usage
|
Synthesis Reference(s) |
The Journal of Organic Chemistry, 29, p. 3042, 1964 DOI: 10.1021/jo01033a061 |
InChI:InChI=1/C6H2F4/c7-3-1-4(8)6(10)2-5(3)9/h1-2H
327-54-8 Relevant articles
Study of the decarboxylation mechanism of fluorobenzoic acids by strong N-bases
Gierczyk, Blazej,Wojciechowski, Grzegorz,Brzezinski, Bogumil,Grech, Eugeniusz,Schroeder, Grzegorz
, p. 691 - 696 (2001)
The kinetics of the decarboxylation reac...
Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with trans-[Ru(NHC)4H2] through a Concerted Nucleophilic Ru?H Attack Pathway
Cybulski, Mateusz K.,McKay, David,Macgregor, Stuart A.,Mahon, Mary F.,Whittlesey, Michael K.
, p. 1515 - 1519 (2017)
The efficient and highly selective room ...
Competition of Nucleophilic Aromatic Substitution, σ-Bond Metathesis, and syn Hydrometalation in Titanium(III)-Catalyzed Hydrodefluorination of Arenes
Krüger, Juliane,Leppkes, Jakob,Ehm, Christian,Lentz, Dieter
, p. 3062 - 3071 (2016)
Several functionalized and non-functiona...
Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key intermediates
Zámostná, Lada,Ahrens, Mike,Braun, Thomas
, p. 132 - 142 (2013)
Stoichiometric and catalytic hydrodefluo...
NHC·Alane Adducts as Hydride Sources in the Hydrodefluorination of Fluoroaromatics and Fluoroolefins
Schneider, Heidi,Hock, Andreas,Jaeger, Alma D.,Lentz, Dieter,Radius, Udo
, p. 4031 - 4043 (2018)
We present herein the utilization of NHC...
Ring-expanded N-heterocyclic carbene complexes of rhodium with bifluoride, fluoride, and fluoroaryl ligands
Segarra, Candela,Mas-Marza, Elena,Lowe, John P.,Mahon, Mary F.,Poulten, Rebecca C.,Whittlesey, Michael K.
, p. 8584 - 8590 (2012)
Thermolysis of Rh(PPh3)4H in the presenc...
Decisive steps of the hydrodefluorination of fluoroaromatics using [Ni(NHC)2]
Fischer, Peter,Goetz, Kathrin,Eichhorn, Antonius,Radius, Udo
, p. 1374 - 1383 (2012)
The hydrodefluorination reaction of perf...
Selectively catalytic hydrodefluorination of perfluoroarenes by Co(PMe 3)4 with sodium formate as reducing agent and mechanism study
Li, Junye,Zheng, Tingting,Sun, Hongjian,Li, Xiaoyan
, p. 13048 - 13053 (2013)
Successful selective hydrodefluorination...
Catalytic C-F bond hydrogenolysis of fluoroaromatics by [(η5-C5Me5)RhI(2,2′-bipyridine)]
Nakai, Hidetaka,Jeong, Kihun,Matsumoto, Takahiro,Ogo, Seiji
, p. 4349 - 4352 (2014)
A new class of efficient catalyst, the R...
Catalyst-Free Hydrodefluorination of Perfluoroarenes with NaBH4
Schoch, Timothy D.,Mondal, Mukulesh,Weaver, Jimmie D.
supporting information, p. 1588 - 1593 (2021/03/03)
Presented is an economical means of remo...
Catalytic Hydrodefluorination via Oxidative Addition, Ligand Metathesis, and Reductive Elimination at Bi(I)/Bi(III) Centers
Cornella, Josep,Katzenburg, Felix,Leutzsch, Markus,N?thling, Nils,Pang, Yue
, p. 12487 - 12493 (2021/08/30)
Herein, we report a hydrodefluorination ...
New catalytic systems with chemically fixed nickel complexes in the reactions of reductive activation of C-F bonds in ionic liquid media
Adonin, N Yu,Prikhod'ko, S. A.,Shabalin, A Yu.
, (2021/08/03)
The nickel complexes with bidentate nitr...
Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Prehydrolytic Pathways and Self-/Auto-Catalysis
Assante, Michele,Geogheghan, Katherine J.,Hayes, Hannah L. D.,Jin, Na,Leach, Andrew G.,Lloyd-Jones, Guy C.,Noonan, Gary,Tomasi, Simone,Wei, Ran
supporting information, p. 14814 - 14826 (2021/09/13)
The kinetics and mechanism of the base-c...
327-54-8 Process route
-
-
67-56-1
methanol
-
-
1835-49-0
tetrafluoroterephthalonitrile
-
-
327-54-8
1,2,4,5-Tetrafluorobenzene
-
-
5216-17-1
2,3,5,6-tetrafluorobenzonitrile
-
-
89992-52-9
2,3,5,6-tetrafluorobenzylamine
-
-
3217-47-8
2,3,5,6-tetrafluoroterephthalaldehyde
| Conditions | Yield |
|---|---|
|
methanol; tetrafluoroterephthalonitrile;
With
sulfuric acid; hydrogen;
5% rhodium-on-charcoal;
at 20 - 80 ℃;
for 5.5 - 8.3h;
With
water;
at 100 ℃;
for 1h;
Product distribution / selectivity;
|
|
|
methanol; tetrafluoroterephthalonitrile;
With
sulfuric acid; hydrogen;
2% Rh/C;
at 70 ℃;
for 7.3h;
With
water;
at 100 ℃;
for 1h;
Product distribution / selectivity;
|
-
-
67-56-1
methanol
-
-
1835-49-0
tetrafluoroterephthalonitrile
-
-
2,3,5,6-tetrafluoro-4-formylbenzonitrile
-
-
327-54-8
1,2,4,5-Tetrafluorobenzene
-
-
5216-17-1
2,3,5,6-tetrafluorobenzonitrile
-
-
3217-47-8
2,3,5,6-tetrafluoroterephthalaldehyde
| Conditions | Yield |
|---|---|
|
methanol; tetrafluoroterephthalonitrile;
With
sulfuric acid; hydrogen;
5% rhodium-on-charcoal;
at 120 ℃;
for 8h;
With
water;
at 100 ℃;
for 1h;
Product distribution / selectivity;
|
327-54-8 Upstream products
-
367-34-0
2,4,5-trifluoroaniline
-
95-94-3
1,2,4,5-tetrachlorobenzene
-
363-72-4
Pentafluorobenzene
-
75410-99-0
1,2,4,5-tetrafluorobicyclo <2.2.0> hexa-2,5-diene
327-54-8 Downstream products
-
344-03-6
1,4-dibromotetrafluorobenzene
-
392-57-4
1,4-diiodo-2,3,5,6-tetrafluorobenzene
-
327-55-9
2,5-Difluoro-1,4-benzoquinone
-
377-69-5
1,2,3,4,5,6-hexachloro-1,2,4,5-tetrafluoro-cyclohexane
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